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HumanKine™ BMP-4

HumanKine™ BMP-4
Prod. No.

Recombinant human BMP-4 expressed in engineered human cells. BMP-4 belongs to the bone morphogenic protein family that is a subgroup of the TGF-beta superfamily. BMP-4 is a 34 kDa glycosylated homodimer with a dilsulfide linkage. BMP-4 provides ventralizing signals for existing mesoderm and has a crucial role in mammalian hematopoietic stem cells. This cytokine is important to the onset of endochondral bone formation in humans and is expressed from early embryogenesis through adulthood. BMP-4 is essential in epidermal determination, the development of multiple organs, tissue repair, mesenchyme formation, and suppression of neural induction.

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