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HumanKine™ IL-12

HumanKine™ IL-12
Prod. No.

Recombinant human IL-12 expressed in engineered human cells. IL-12 belongs to the IL-6/IL-12 protein family. IL-12 is a 57 kDa heterodimeric glycoprotein; the subunits p35 and p40 are linked with a disulfide bond. The p40 dimer can bind to IL-12 receptor and antagonizes IL-12. Most of cell types express the p35 chain, while the p40 chain is restricted to dendritic cells, B-cells and cells of macrophage /monocytes lineage. IL-12 is produced by macrophages and B-lymphocytes and is induced by both innate and adaptive immune responses. IL-12 may induce T-cell proliferation towards the Th1 phenotype.

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