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HumanKine™ IL-4

HumanKine™ IL-4
Prod. No.

Recombinant human IL-4 expressed in engineered human cells. IL-4 is a 14 to 19 kDa glycoslyated monomer and belongs to the IL -4/IL-13 protein family. IL-4 is produced by a number of hematopoietic cell types such as Th2, NK-T, CD3+, as well as basophils, eosinophils, and mast cells. Human IL-4 is important in several B-cell and T-cell activation pathways such as differentiation and proliferation. IL-4 aids antigen presentation on B cells by increasing expression of class II MHC and is implicated in isotype switching of immunoglobulins. Secretion and cell surface expression of IgE and IgG1 on B-cells is enhanced by IL-4. IL-4 inhibits the production of inflammatory cytokines such as TNF-alpha, and IL-1 and prevents the growth of some cancers.

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