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HumanKine™ LEFTY-1

HumanKine™ LEFTY-1
Prod. No.

Recombinant human LEFTY-1 expressed in engineered human cells. LEFTY-1 is a 38 kDa glycosylated monomer and belongs to the TGFβ superfamily. LEFTY-1 is required for left-right axis determination as a regulator of LEFTY-2 and NODAL. In the presence of LEFTY-1, LEFTY-2 and NODAL expression is restricted to the left side of organ systems during development. Clinical studies of patients with mutations in the LEFTY-1 gene confirm abnormalities in the thorax and cardiac anatomy.

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