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HumanKine™ Noggin

HumanKine™ Noggin
Prod. No.

Recombinant human Noggin, expressed in engineered human cells. Noggin is a 65 kDa, disulfide linked homodimeric glycoprotein and belongs to the Noggin protein family. It has a primary structure consisting of an acidic amino-terminal and a cysteine-rich carboxyterminal. In mammals, Noggin is expressed primarily in the central nervous system. Noggin binds to and inactivates bone morphogenetic proteins including BMP-2, BMP-4 and BMP-7, preventing the activation of BMP receptors. Noggin is essential for proper skeletal development and enhances the survival and induces the growth of nerve and muscle cells.

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