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HumanKine™ TGF beta 1

HumanKine™ TGF beta 1
Prod. No.

Recombinant human Transforming Growth Factor (TGF) beta 1 expressed in engineered human cells. TGF beta 1 is a 25 kDa dilufide linked homodimeric protein and belongs to the TGF beta superfamily. TGF beta 1 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis. TGF beta 1 is crucial in cell growth, differentiation, and survival. TGF beta 1 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblasts, and keratinocytes cells. TGF beta 1 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelialmesenchymal transition and stimulating angiogenesis. TGF beta 1 inhibits NK cell growth as well as B and T cell proliferation.

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