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HumanKine™ TNF alpha

HumanKine™ TNF alpha
Prod. No.
S2342
$0.00

Recombinant human Tumor Necrosis Factor (TNF) alpha expressed in engineered human cells. TNF alpha is a 17 kDa non-disulfide linked homotrimeric glycoprotein belongs to the Tumor Necrosis Factor protein family. TNF alpha is a proinflammatory cytokine produced in response to infection, tissue damage and inflammation by many immune cells such as monocytes and macrophages. TNF alpha is an acute phase protein that initiates production of other cytokines; it recruits neutrophils and macrophages at the site of infection by increasing the vascular permeability. TNF alpha synergizes with other cytokines including IL-1 beta, IFN gamma, and TGF beta. Genetic variations in TNF alpha are correlated with autoimmune diseases.

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