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HumanKine™ VEGF121

HumanKine™ VEGF121
Prod. No.

Recombinant human VEGF121 expressed in engineered human cells. VEGF121 is a 37kDa homodimeric, 50kDa homotrimeric disulfide-linked glycoprotein and belongs to the PDGF/VEGF growth factor family. Many cell types secrete VEGF and it is a potent angiogenic factor and mitogen that stimulates proliferation, migration, and formation of endothelial cells. VEGF stimulates permeabilization of blood vessels and is present in some tumors of nervous system. VEGF is induced by hypoxia, oncogene mutations, and cytokines such as IL-1, IL-8, TNF-α.

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