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Lin28 Monoclonal Antibody PR-3G10

Lin28 Monoclonal Antibody PR-3G10
Prod. No.
S2109-100UG
$300.00

Background

Human Lin28, encoded by the LIN28 gene, is a cytoplasmic mRNA-binding protein with a cold shock domain and two CHCC-type zinc fingers. It has been shown to enhance translation of IGF-2 mRNA and to block processing of let-7 microRNA. Lin28 is a marker for undifferentiated embryonic stem cells, and Lin28 expression has been used to enhance the generation of induced pluripotent stem (iPS) cells.



Citations
Meirelles, K., Benedict, L.A., Dombkowski, D. et al. (2012). "Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance" Proc. Natl. Acad. Sci. USA 109:2358-2363. Free full text in PMC


Clone: PR-3G10
Reacts with: Human, Mouse*
Tested Applications: WB, ELISA, Dot
Host: Mouse
Isotype: IgG1, κ
Size: 100 µg
Immunogen: Synthetic peptide derived from human Lin28 (within 50 amino acids of N-terminus) conjugated to ovalbumin carrier protein.

Purification: Protein G chromatography
Formulation: 1 mg/ml in PBS; Preservative: 0.09% NaN3
Storage:Store at 4ºC (<3 months) or -20ºC. Avoid multiple freeze-thaws.

Recommended Uses:
Western Blot 1:500
ELISA (detect) 1:1000
Dot blot (detect) 1:500
Note: Optimal concentrations should be empirically determined.
*Other species not tested


Target Alternative Names: Protein lin-28 homolog A, Lin-28A, Zinc finger CCHC domain-containing protein
Target Size:209 AA; 22.7 kDa
Target Database Links:
RefSeq Protein NP_078950
RefSeq Gene NM_024674
UniProt Q9H9Z2

S2109

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